The fifth-year residents return for the first day of a year that will make or break their careers as the eighth season of Grey's Anatomy premieres.
Meredith faces the consequences of tampering with Derek's clinical trial and is terminated at the hospital; April tries to step up to the plate as Chief Resident in the wake of a giant sinkhole in the middle of Seattle; and Cristina and Owen are still at odds over their drastically different feelings for their unborn child.
Season 8 stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey, Kevin McKidd as Owen Hunt, Jessica Capshaw as Arizona Robbins, Kim Raver as Teddy Altman, Sarah Drew as Dr. April Kepner and Jesse Williams as Dr. Jackson Avery.
Grey's Anatomy was created and is executive-produced by Shonda Rhimes. Betsy Beers, Mark Gordon, Krista Vernoff, Rob Corn, Mark Wilding and Allan Heinberg are executive producers. Grey's Anatomy is an ABC Studios production.