The interns of Grey's Anatomy return for their third season of living and loving. They've learned a lot since their first year at Seattle Grace Hospital - not only about surgery, but about themselves and one another.
There’s Izzie, who has decided there may be more in her life than medicine after falling in love with Denny, a patient whose life she fought to save … and lost. Now that she’s quit the intern program, Izzie will see what a future without the hospital has in store.
Her best friend George has had his own ups and downs in love. Having his dreams of a relationship with Meredith crushed after a demoralizing one-night stand with her, George found love in the unlikeliest of people - the tough, unique Orthopedic Surgeon Dr. Callie Torres.
Callie sees and loves all of the qualities that make George who he is, and in return George likes her being the kind of woman who will stand up for him and their relationship.
Alex Karev may be the surgical intern all of the other interns love to hate, but the cocky and often callous Alex has been there for his fellow students when it matters.
Focused and ambitious intern Cristina Yang has wanted one thing her whole life: to become a talented and successful surgeon. Cristina, who once lacked all bedside manner, is now allowing her allegiances to friends and her emotions to seep into her work.
One of her greatest emotional challenges is yet to come, as she must become a source of support and assistance to her boyfriend, Cardiothoracic Surgeon Dr. Preston Burke. Highly respected amongst his fellow surgeons, Burke must deal with a potentially career-ending tremor in his hand, the result of a near-fatal shooting accident at the hospital.
And then there’s Meredith Grey. After Meredith and Derek “McDreamy” Shepherd’s ever-present sexual tension culminated in a moment of passion, they have to face the consequences.
Meredith was just beginning to fall for the attractive and available veterinarian, Finn and there’s the matter of Derek’s wife, Addison. A neonatal surgeon at the hospital, Addison is a woman trying to put her own indiscretions in the past to save her marriage.
The interns, as always, will be under the guidance of “The Nazi,” Dr. Miranda Bailey, who both terrorizes and nurtures them. Bailey maintains a tough exterior, but with these interns, it’s hard not to display her softer side from time to time.
Supervising the whole operation is The Chief, Dr. Richard Webber. His past indiscretions with Meredith’s mother, Ellis, have been exposed and he must now deal with the consequences to his family and professional life.
The first episode of the season sees everyone helping Izzie cope with the loss of Denny and her decision to quit the internship program. Meredith must decide what the future holds after her hospital liaison with Derek.
The Chief is confronted by his wife, Adele, after spending the night in his office, and George seeks relationship advice from a surprising source.