The Authority is in flames. TruBlood is in short supply. As Bill comes to terms with his newfound powers after emerging reincarnated from a pool of blood, humans are in open conflict with vampires like never before.
Meanwhile, Sookie and Jason must steel themselves for an encounter with their parents' killer: the mysterious and ancient Warlow.
Mixing romance, suspense, mystery and humour, the show takes place in a world where vampires and humans co-exist, after vampires have come out of the coffin, thanks to the invention of mass-produced synthetic blood that means they no longer need humans as a nutritional source.
The series follows waitress and part-faerie Sookie Stackhouse (Anna Paquin), who can hear people's thoughts, vampire Bill Compton (Stephen Moyer) and vampire Eric Northman (Alexander Skarsgård).
Alan Ball (creator of the Emmy-winning HBO series Six Feet Under) created the show, which is based on the bestselling Sookie Stackhouse novels by Charlaine Harris.
Other returning cast members on Season 6 include: Ryan Kwanten as Sookie's trouble-prone brother, Jason Stackhouse; Rutina Wesley as Pam's newly-turned progeny, Tara Thornton; Sam Trammell as Sookie's shape-shifting boss, Sam Merlotte; and Nelsan Ellis as Tara's clairvoyant sharp-tongued cousin, Lafayette Reynolds.
Also returning this season are Carrie Preston as Arlene Bellefleur, a Merlotte's waitress; Todd Lowe as Terry Bellefleur; Chris Bauer as Terry's cousin, sheriff Andy Bellefleur; Deborah Ann Woll as Jessica Hamby, Bill's vampire progeny; and Kristin Bauer van Straten as Pam, Eric's vampire progeny and business partner.
There's also Lauren Bowles as Holly, a Merlotte's waitress; Joe Manganiello as werewolf Alcide; Michael McMillian as vampire Steve Newlin; Lucy Griffiths as Nora, a former chancellor of the Vampire Authority; Kelly Overton as werewolf Rikki; and Anna Camp as anti-vampire crusader Sarah Newlin.
New cast members for Season 6 include: Arliss Howard as Louisiana Governor Truman Burrell; Rob Kazinsky as Ben, a stranger with faerie ties; Rutger Hauer as Niall, a faerie grandfather; Jurnee Smollett-Bell as Nicole, a pro-vampire activist; and Amelia Rose-Blaire as Truman Burrell's daughter, Willa.
In the first episode of Season 6, entitled "Who Are You, Really?": in the wake of Bill's (Stephen Moyer) blood-soaked reincarnation, Sookie, Eric, Jason, Jessica, Tara, Pam and Nora flee the Authority compound as Sam, Luna (Janina Gavankar) and Emma (Chloe Noelle) dodge swarming guards.
Now packmaster, Alcide discovers that the job comes with unsavoury side dishes, but other major perks. In Bon Temps, Andy deals with parenting four newborn human-faerie hybrids.
Meanwhile, Louisiana Governor Truman Burrell vows open season on vampires. Jessica returns to Compton Place as Jason hitches a ride with an eerie stranger.
True Blood was created by Alan Ball; based on the Sookie Stackhouse novels by Charlaine Harris; executive producers, Alan Ball, Brian Buckner, Gregg Fienberg, Mark Hudis,Alexander Woo and Raelle Tucker; co-executive producers, Angela Robinson and Rob DesHotel; supervising producer, Robin Veith; co-producer, Christina Jokanovich.