Mixing romance, suspense, mystery and humour, the series takes place in a world where vampires and humans co-exist, after vampires have come out of the coffin, thanks to the invention of mass-produced synthetic blood invented by a Japanese scientist that means they no longer need humans as a nutritional source.
The series follows waitress and part-faerie Sookie Stackhouse (Anna Paquin), who can hear people's thoughts, and vampires Bill Compton (Stephen Moyer) and Eric Northman (Alexander Skarsgård).
Thanks to the invention of True Blood, vampires have progressed from legendary monsters to fellow citizens overnight. And while humans have been safely removed from the menu, many remain apprehensive about these creatures "coming out of the coffin."
Religious leaders and government officials around the world have chosen their sides, but in the small Louisiana town of Bon Temps, the jury is still out.
Local waitress Sookie Stackhouse (Anna Paquin), however, knows how it feels to be an outcast. "Cursed" with the ability to listen in on people's thoughts, she's also open-minded about the integration of vampires — particularly when it comes to Bill Compton (Stephen Moyer), a handsome 173-year-old living up the road.
But as Sookie is drawn into a series of mysteries surrounding Bill's arrival in Bon Temps, that tolerance will be put to the test.
True Blood was created by Alan Ball; based on the Sookie Stackhouse novels by Charlaine Harris; executive producers, Alan Ball, Brian Buckner, Gregg Fienberg and Angela Robinson; co-executive producer, Howard Deutch; supervising producer, Kate Barnow; producers, David Auge and Bruce Dunn; co-producers, Christina Jokanovich, Ronald Cosmo Vecchiarelli and Sunday Stevens.