Christina Applegate is an American actress best known for her television roles as dim-witted Kelly Bundy on Married... with Children (1987-1997), and as the title character in Samantha Who?, from 2007-2009.
She also starred as Reagan Brinkley, a career-driven and energetic woman trying to juggle the demands of career, marriage and motherhood, in the television sitcom Up All Night, from 2011-2012.
After receiving accolades for her performance starring alongside Cameron Diaz and Selma Blair in the raucous feature comedy The Sweetest Thing, Applegate's range of skill landed her numerous roles in both independent and studio projects.
Her feature film credits include Surviving Christmas, for director Mike Mitchell; the comedy Anchorman: The Legend of Ron Burgundy; the dark comedy Employee of the Month; the indie film Grand Theft Parsons, for director David Caffrey; Wonderland; View from the Top; Don't Tell Mom the Babysitter's Dead; and Mars Attacks!.
She can also be seen in the comedy feature The Rocker, with Rainn Wilson (The Office) and directed by Peter Cattaneo (The Full Monty).
Applegate made her Broadway debut in the revival of Sweet Charity, in the starring role of Charity Hope Valentine. For her role, she was nominated for a Tony Award for Best Performance by a Leading Actress in a Musical, as well as a Drama Desk Award in the category of Outstanding Actress in a Musical.
Sweet Charity ended its run in January 2006.
Other stage credits include an appearance in John Cassavetes' Los Angeles production of The Third Day, with Gena Rowlands, The Axeman's Jazz, Nobody Leaves Empty Handed, The Run-Through and The Grass Harp.
Applegate first gained widespread attention as the sexy and sarcastic Kelly Bundy on the long-running series Married with Children. After a very successful 11-season run, she furthered her television success by starring in her own comedy series, Jesse.
In 1999 the highly-rated show garnered Applegate a People's Choice Award as Favorite Female Performer in a New Television Series and a Golden Globe nomination in the category of Best Performance by an Actress in a TV Series, Comedy or Musical.
In 2004 Applegate returned to television as a guest star on Friends, as Rachel's (Jennifer Aniston) younger sister, Amy. Her performance earned her an Emmy Award in the category of Outstanding Guest Actress in a Comedy Series for her role.
She was nominated for an Emmy once again the following year for yet another witty performance.
Applegate has garnered a Golden Globe nomination and Screen Actors Guild Award nomination for her role on Samantha Who?.
On August 3, 2008, People Magazine reported that Applegate had been diagnosed with breast cancer. On August 19, 2008, it was announced that she is cancer free after a double mastectomy, even though cancer was found in only one breast.
She was married to actor Johnathon Schaech from 2001-2006.