New York City, 1901: The Knick faces an upheaval, as Dr. John Thackery's absence (due to his hospitalisation for cocaine addiction), a dearth of affluent patients, and financial missteps have led to the board's decision to shutter The Knickerbocker Hospital in favour of a new building uptown.
In this world of corruption, invention and progress, everyone is searching for the new path that will help him or her survive. Whether it's a path toward justice, freedom, love or just plain survival, nothing comes easy.
As relocation plans proceed, the gifted but under-appreciated Dr. Algernon Edwards (André Holland) jockeys to become Thackery's successor as chief of surgery, while fellow doctors, nurses, nuns and administrators grapple with challenges at work and in their private lives.
In the first episode of Season 2, "Ten Knots": as Barrow (Jeremy Bobb) and The Knick prepare to move uptown, Dr. Edwards lobbies the hospital board to be appointed permanent chief of surgery in Dr. Thackery's (Clive Owen) absence.
Though his suspension has been lifted, Dr. Gallinger (Eric Johnson) refuses to return as Edwards' subordinate, so he heads to Cromartie Hospital in hopes of getting Thackery to return to work.
Lucy's (Eve Hewson) attempts to make amends with Bertie (Michael Angarano) are rebuffed; Cleary (Chris Sullivan) schemes to make extra money; Ping Wu (Perry Yung) demands regular medical checkups for his prostitutes; Speight (David Fierro) attempts to trace the origins of a new plague; and Cornelia (Juliet Rylance) nourishes a quarantined neighbourhood in San Francisco.
Starring Clive Owen, André Holland, Eve Hewson and Juliet Rylance, the entire second season is directed by Steven Soderbergh.