In the aftermath of their journey to another planet, Director Phil Coulson and the rest of the team were driven more than ever to put an end to the Hydra organisation.
Little did they know that they were up against the deadliest threat they've ever faced - an extremely powerful Inhuman, Hive, who was transported back from Maveth in the body of their worst enemy, Grant Ward.
The team was able to thwart and kill Hive and take down Hydra, but they are all still mourning the death of fellow agent and Inhuman Lincoln Campbell.
In light of the Sokovia Accords, and with Hydra obliterated, S.H.I.E.L.D. has been legitimatised again and no longer needs to operate in the shadows. Since the world presumes that Coulson is dead, the organisation needed a new Director to be the face of the organisation.
Coulson finds himself back in the role as an agent and teamed with Mack, and together they are tasked with tracking down and confirming the presence of Enhanced people, aka Inhumans. Agent May is tasked with training specialist strike teams, and Fitz and Simmons have taken a big step forward in their relationship.
In the season premiere episode, Ghost Rider is coming, and S.H.I.E.L.D will never be the same.
Season 4 stars Clark Gregg as Agent Phil Coulson, Ming-Na Wen as Agent Melinda May, Chloe Bennet as Daisy Johnson, Iain De Caestecker as Agent Leo Fitz, Elizabeth Henstridge as Agent Jemma Simmons, Henry Simmons as Agent Alphonso "Mack" MacKenzie and John Hannah as Holden Radcliffe.
Produced by ABC Studios and Marvel Television, Agents of S.H.I.E.L.D. was co-created by Joss Whedon, Jed Whedon and Maurissa Tancharoen, who also serve as executive producers along with Jeffrey Bell and Jeph Loeb.