Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out - after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon.
But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama.
Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.
She quickly finds that Southern hospitality isn't always so hospitable - the other doctor in town, Brick Breeland, is less than pleased to be sharing the practice with this young outsider, and his daughter, Lemon, is a Southern belle whose sweet disposition turns sour when she meets Zoe.
Zoe's only allies are the mayor, former football star Lavon Hayes, her bad-boy neighbour Wade Kinsella, and handsome lawyer George Tucker - who just happens to be Lemon's fiance.
Zoe is out of her element and ready to pack her bags, but a surprise visit by her snobby New York mother leads to Zoe's decision to stay in Bluebell for a while, discovering small-town life and a side of herself she hadn't known was there.
The series stars Rachel Bilson as Dr. Zoe Hart, Jamie King as Lemon Breeland, Wilson Bethel as Wade Kinsella, Cress Williams as Lavon Hayes and Scott Porter as George Tucker.
Hart of Dixie is from Bonanza Productions Inc., in association with Fake Empire, Warner Bros. Television and CBS Television Studios, with executive producers Leila Gerstein (Gossip Girl, Eli Stone), Josh Schwartz (Gossip Girl, Chuck, The O.C.), Stephanie Savage (Gossip Girl, The O.C.), Len Goldstein and Jason Ensler (Gossip Girl, Chuck).
The pilot was directed by Jason Ensler.