This season, Cathy sets about finding more joy in her life. Mamie Gummer (Off the Map, The Good Wife) and Hamish Linklater (The New Adventures of Old Christine) star as a young couple who could give Cathy a shot at said joy with an unexpected offer.
Meanwhile, Tim (Brian D'Arcy James) will help Sean (John Benjamin Hickey) get over his past relationship in a most unusual way.
Other guest stars this season include Susan Sarandon as motivational speaker Joy; Alan Alda returns as Cathy's oncologist; Allison Janney will play a famous Hollywood producer; Victor Garber's Willy Wanker and Sean will go mano-a-mano over ownership of an adult phone line; and Tammy Blanchard plays Giselle, who unintentionally brings some much-needed order to Sean's chaotic life.
The series focuses on Cathy Jamison (Linney), a reserved, suburban wife/mother/teacher whose terminal cancer diagnosis forces her to shake up her life and find the light side of a dark situation.
The Big C was created and written by Darlene Hunt, who serves as executive producer, along with writer/showrunner Jenny Bicks, Laura Linney, Neal H. Moritz and Vivian Cannon. It was produced by Sony Pictures Television.