Just when they thought they were out, they are pulled back in – for the most dangerous escape ever.
Entering its dramatic and action-packed third season, Prison Break finds Michael Scofield wrongly incarcerated in Sona, a hellish Panamanian prison where there are no rules, no guards and no escape.
After successfully breaking his older brother Lincoln Burrows out of Fox River Penitentiary for a murder he did not commit (Season One), Michael, Lincoln and several other convicts were the targets of a nationwide manhunt that eventually led them to tropical Panama (Season Two).
Despite Lincoln's exoneration for his alleged crimes, the brothers' freedom and happiness were short-lived as Michael was framed and sent to Sona Prison by “The Company,” the same government conspiracy that originally put Lincoln behind bars.
Michael soon discovers that he was purposely placed in Sona to engineer another daring and seemingly impossible prison break – this time in order to free Whistler, a mysterious inmate hiding within the prison's sewer system.
Sona (inspired by the actual Carandiru Prison in Brazil) is unlike any American prison. A murderous riot among the inmates has driven all guards and authorities from the premises, leaving the prison with its own warped hierarchy and code of ethics created and ruled by vicious drug kingpin Lechero.
Once inside Sona, Michael must avert Lechero's suspicions and wrath while protecting himself from a trio of enemies: Alex Mahone, the renegade FBI agent who was revealed to be involved with The Company; Brad Bellick, the former Fox River prison-guard-turned-hapless-bounty-hunter; and the one-handed, homicidal paedophile Theodore 'T-Bag' Bagwell – making Michael's plans for escape even more difficult and complicated.
With the tables turned this time around, Lincoln must work outside the prison walls to help pull off the escape, as well as rescue his kidnapped son, LJ, and Michael's true love, Sara Tancredi.
In Panama, Lincoln is reunited with fellow Fox River escapee Fernando Sucre and becomes involved with two beautiful women who will prove to be instrumental to the break – Susan B. Anthony, a cool and deadly operative for The Company; and Sofia, Whistler's innocent girlfriend who is unaware of the danger she is about to encounter.
With the clock ticking, Michael and Lincoln must figure out a way to reunite with their loved ones, bring down The Company and engineer the most thrilling prison break yet.