Hannah has left New York to attend the prestigious Iowa Writers' Workshop, hoping to become a more serious writer, while facing uncertainty in her relationship with Adam.
Back in the city, Marnie is pursuing a music career, trying to balance her personal and professional relationship with Desi.
New graduate Shoshanna is interviewing for jobs and struggling to sort out her relationship with Ray. And Jessa is trying sobriety through AA, but her knack for creating drama is undiminished.
Created by and starring Lena Dunham, Girls takes a comic look at the assorted humiliations and rare triumphs of a group of women in their 20s. Judd Apatow, Jenni Konner, Lena Dunham, Ilene S. Landress, Murray Miller, Paul Simms and Bruce Eric Kaplan executive produce the show.
In addition to Dunham, who stars as Hannah, the Season 4 cast includes Allison Williams as Marnie; Jemima Kirke as Jessa; Zosia Mamet as Shoshanna; Alex Karpovsky as Ray; Adam Driver as Adam; Andrew Rannells as Elijah; and Ebon Moss-Bachrach as Desi.
Returning guest stars for the fourth season of Girls include: Rita Wilson as Marnie's mother; Peter Scolari and Becky Ann Baker as Hannah's parents; Jon Glaser as Laird; Gaby Hoffman as Adam's sister, Caroline; Louise Lasser as Beedie; and Bob Balaban as Dr. Rice.
New guest stars this season include Ana Gasteyer and Anthony Edwards as Shoshanna's parents; Natasha Lyonne as Rickie; Gillian Jacobs as Mimi-Rose Howard; Marc Maron as Ted; Zachary Quinto as Ace; Jason Ritter as Scott; Maude Apatow as Cleo; and Spike Jonze as Marcos.
In the fourth season premiere: After a congratulatory dinner with her parents, Hannah and Adam pack up the last of her boxes and discuss "the plan" for their soon-to-be long-distance relationship.
Marnie and Desi perform as part of a jazz brunch for a distracted crowd at a downtown restaurant. Shoshanna signs for her diploma with her parents, who make a bigger deal out of the event than she thinks necessary.
Jessa is confronted by Beedie's daughter, Rickie (Natasha Lyonne), and later seems nonplussed by Hannah's impending departure.
The regular timeslot for Season 4 on M-Net Edge was Fridays at 21h00, although this transmission was preceded by an "Express TX" broadcast at 03h00 on Tuesdays.