Refilwe Madumo is a South African actress best known for her role as Palesa Mooki-Letswalo, an HIV-positive character, on the e.tv soap opera Scandal!.
She was previously known for her starring role as Thembi on the television sitcom Mazinyo Dot Q.
In 2006 she guest starred on the SABC1 sitcom Izoso Connexion. In 2007 she guest starred on the SABC3 comedy-drama series One Way and she played the role of Zanele in the SABC1 drama series Society, returning for its second season in 2009.
In 2008 played Ruth in the SABC2 miniseries Huis van Liefde.
In 2015 she had a starring role as Dorah in the SABC2 family drama series Mamello.