Set in Toronto at the dawn of the 20th century, Murdoch Mysteries is a one-hour drama series that explores the intriguing world of William Murdoch (Yannick Bisson), a methodical and dashing detective who pioneers innovative forensic techniques to solve some of the city's most gruesome murders.

Murdoch's colleagues again include his beloved wife, the fiery and fiercely intelligent Dr. Julia Ogden (Hélène Joy); Constable George Crabtree (Jonny Harris), Murdoch's eager but sometimes naïve right-hand man; Inspector Thomas Brackenreid (Thomas Craig), Murdoch's sceptical yet reluctantly supportive boss; and morgue assistant Rebecca James (Mouna Traoré), a resourceful young medical student taken under Ogden's mentorship.

All are valuable allies who help Murdoch solve his varied cases and traverse the many stratums and evolving manners of Victorian-turned-Edwardian society.

Season 11 begins with Murdoch jailed and framed for the murder of a burlesque dancer. His constables were gunned down in an ambush, Brackenreid was last seen with a gun to his head, and the corrupt politician and his cronies responsible kidnapped Ogden.

Murdoch must prove his innocence from behind bars, as Detective Llewellyn Watts helps covertly to solve the case.

Upcoming cases feature the return of Alexander Graham Bell, who assists Murdoch after a guest is murdered at a unique dinner honouring Helen Keller; and a bizarre automobile accident must be solved before a deadly deadline.

Later, a radical surgeon's attempts to perform an organ transplant operation are disrupted by Christian Science founder Mary Baker Eddy; after a painter is found murdered, Brackenreid picks up his paintbrush again to investigate, attracting the attention of a lascivious patron; and when a series of elderly men commit suicide, overzealous reporter Louise Cherry lambastes Dr. Charles Osler, the father of modern medicine.